Apple Powder, Pomme, Ringo @ amazondiscovery.com - May 14, 2014!

Apple Information & Purchase

Apple Powder, Pomme, Ringo

Also Known As:

Abilde, Almindelig Aeble, Apfel, Apfelbaum, Äppel, Äppelträd, Apple Tree, Eble, Echter Apfelbaum, Iabloko, Iablonia, Jablon Domáca, Kultur-Apfel, Maça, Maçanzeira, Maceira, Macieira, Manzana, Manzano, Mela, Melo, Paratiisiomena, Ping Guo, Pomme, Pommier, Pomo, Pommier Commun, Ringo, Seiyou Ringo, Tarhaomenapuu, Tuffahh, Žlahtna jablana. CAUTION: See separate listing for Apple Cider Vinegar and Pectin.

Scientific Name:

Malus domestica. Synonyms: Malus sylvestris, Malus malus, Malus pumila, Pyrus malus. Family: Rosaceae.

People Use This For:

Orally, apple powder is used to control diarrhea or constipation, and for the softening, passage and collection of gallstones. Apple powder is also used for treating cancer, diabetes, dysentery, fever, heart ailments, scurvy, warts and for cleaning teeth.

Safety:

LIKELY SAFE ...when used orally in food amounts. Tell patients to avoid eating apple seeds, which can be toxic. PREGNANCY AND LACTATION: There is insufficient reliable information available about the safety of apple in medicinal amounts during pregnancy and lactation; avoid using.

Effectiveness:

INSUFFICIENT RELIABLE EVIDENCE TO RATE Gallbladder disease. There is some preliminary evidence that apple juice powder used orally for seven days, with olive oil used on the seventh day before going to bed, might be effective for the softening, passage and collection of gallstones in the stool.
Lung cancer. There is some preliminary evidence that increasing apple consumption might decrease the risk of developing lung cancer.
Weight loss. Preliminary research suggests that eating apples three times daily is associated with 1.22 kg weight loss after 12 weeks in overweight women. Weight loss was modest, but significantly greater than control.
More evidence is needed to rate apple for these uses.

Mechanism of Action:

The applicable part of apple is the fruit, which can also be consumed as apple fruit powder and apple powder extract. Apple contains polyphenols and pectin that may be responsible for some of its effects.
Apple polyphenols can provide a number of health benefits. Polyphenols are antioxidants which can reduce free radicals, cell-damaging molecules which are often responsible for cancer. Polyphenols may also enhance the immune responses of the body and promote cell repair.
The pectin in apple powder extract and apple fruit powder probably accounts for its effect on diarrhea and constipation. Pectin absorbs water in the gastrointestinal (GI) tract and swells to a gummy mass. The mass provides bulk which tends to normalize bowel function.
Apple skin also contains ursolic acid, which is a triterpenoid that contributes to the waxy coat on apple skins. Research in animal models suggests that ursolic acid might have an effect on muscle mass. In animals fed ursolic acid, muscle mass, exercise capacity and grip strength increased. Ursolic acid also increases amounts of brown fat. Additionally, animals fed ursolic acid had increased calorie expenditure, decreased weight and improved glucose tolerance. Based on these data, there is interest in using apple extracts of ursolic acid in the form of an apple powder in supplements promoted for weight loss.
There is some interest in using apples for improving lung function. There is some evidence that consuming five or more apples per week can improve lung function as measured by maximum forced expiration in one second (FEV1). The constituent quercetin is an antioxidant flavonoid found in high concentrations in apples. Quercetin is thought to be responsible for apple's potential benefit in preventing lung cancer.
Apples also contain phloretin, which has antibacterial activity. Apple juice or apple juice powder is thought to inhibit the drug transporter protein, organic anion-transporting polypeptide (OATP), which reduces bioavailability of OATP substrates. Fexofenadine (Allegra) is a substrate of OATP. Clinical research shows that coadministration of apple juice or apple juice powder decreases bioavailability of fexofenadine by about 78%. In an animal model, apple juice decreased bioavailability of fexofenadine by 22%. It is thought that apple juice or apple juice powder might affect OATPfor only a short time. Therefore, separating drug administration and consumption of apple juice or apple juice powder by at least 4 hours might avoid this interaction.

Adverse Reactions:

No adverse reactions are generally known or predicted to occur with apple fruit or apple powder. However, one death has been attributed to ingestion of a large amount (a cupful) of apple seeds, which contain hydrogen cyanide (HCN). Ingestion of large amounts of apple seeds may cause cyanide poisoning, leading to death. To release cyanide, apple seeds must be hydrolyzed in the stomach, and several hours may elapse before poisoning symptoms occur. Patients allergic to other fruits in the Rosaceae family can also be allergic to apples. Cross-reactivity among the apple fruit and other members of the Rosaceae family, including apricot, almond, plum, peach, pear and strawberry, has been demonstrated.

Interactions with Herbs & Supplements:

None known.

Interactions with Drugs:

ATENOLOL (Tenormin) Interaction Rating = Major. Do not take this combination. Consuming apple juice or apple juice powder can significantly decrease oral absorption and blood levels of atenolol when used together. Pharmacokinetic research shows that coadministration of apple juice 600-1200 mL decreases levels of atenolol by 58% to 82% in a dose-dependent manner.
Apple juice pr apple juice powder seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver and kidney. It is thought that apple juice or apple juice powder might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice or apple juice powder by at least 4 hours might avoid this interaction.
FEXOFENADINE (Allegra) Interaction Rating = Moderate. Be cautious with this combination. Consuming apple juice or apple juice powder can significantly decrease oral absorption and blood levels of fexofenadine when used together. Clinical research shows that coadministration of apple juice decreases bioavailability of fexofenadine by about 78%. In an animal model, apple juice decreased bioavailability of fexofenadine by 22%.
Apple juice or apple juice powder seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver and kidney.
It is thought that apple juice or apple juice powder might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice or apple juice powder by at least 4 hours might avoid this interaction.
ORGANIC ANION-TRANSPORTING POLYPEPTIDE SUBSTRATES (OATP) Interaction Rating = Moderate. Be cautious with this combination. Research shows that consuming apple juice or apple juice powder inhibits organic anion transporting polypeptides (OATP), which reduces bioavailability of oral drugs that are substrates of OATP. Fexofenadine (Allegra) is a substrate of OATP. Clinical research shows that coadministration of apple juice decreases bioavailability of fexofenadine by about 78%. In an animal model, apple juice decreased bioavailability of fexofenadine by 22%.
It is thought that apple juice or apple juice powder might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.
Some drugs that are substrates of OATP include bosentan (Tracleer), celiprolol (Celicard, others), etoposide (VePesid), fexofenadine (Allegra), fluoroquinolone antibiotics, glyburide (Micronase, Diabeta), irinotecan (Camptosar), methotrexate, paclitaxel (Taxol), saquinavir (Fortovase, Invirase), rifampin, statins, talinolol, torsemide (Demadex), troglitazone and valsartan (Diovan).

Interactions with Foods:

None known.

Interactions with Lab Tests:

None known.

Interactions with Diseases or Conditions:

CROSS-ALLERGENICITY: Patients allergic to other fruits in the Rosaceae family can also be allergic to apples. Cross-reactivity among the apple fruit and other members of the Rosaceae family, including apricot, almond, plum, peach, pear and strawberry, has been demonstrated.

Dosage/Administration:

ORAL: People typically use 500 mg apple fruit powder or apple powder daily as a supplement. Dried apple peels are used to make a tea: 1 to 2 teaspoons with 1 cup simmering water. The usual dose is from 1 to 3 cups per day. For the softening of gallstones, one liter of apple juice used daily for seven days with 1 cup of olive oil used on the seventh day before going to bed has been used.

Comments:

None.

General Certificate Of Analysis (COA): A manufacture date and batch number are provided for different product strengths. If the link is not available or if the manufacture date and batch number are required, use the email box to request the Certificate of Analysis and we will email it to you as soon as possible. Please enquire about wholesale pricing if purchasing twenty five kilos or more. Please make sure you use the Product ID, Trade Name and Scientific name.


SKU 827 Apple Product Purchase

Kilo Quantity:

"These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease."

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