Calaguala Purchase & Information
Alternative Names
Anapsos, Calaguala, Difur, Fougère, Fern, PLE, PL, P. Leucotomos, Polypodium, Caution: Please refer to separate listing for Lady Fern
Scientific Name
Polypodium Leucotomos
Why Do People Use Calaguala?
The oral preparations of Polypodium leucotomos (Calaguala), like calaguala powder, are utilized for a number purposes that include: • Atopic dermatitis (eczema):
• Prevention of sunburn
• Alzheimer's disease
• Psoriasis
• Vitiligo
• To cure skin and other cancers
Is It Safe To Use?
Likely safe - Polypodium Leucotomos is likely safe to use when utilized for short time, appropriately and orally. Particular extract of calaguala, which includes Cantabria Farmaceutica and Fernblock, is considered likely safe in studies for up to 2 days. Other extract of Polypodium Leucotomos including ASAC Pharma and Anapsos have been considered safe for as much as five months.
However, there is lack of information to rate the safety of calaguala powder, specifically when utilized for long time periods.
For Lactating and Pregnant Women - Females in viable situations like those who are pregnant or breastfeeding their young ones should avoid the use of calaguala powder since there is lack of sufficient reliable information to rate the safety of this product in such conditions.
How Effective Is Calaguala?
Psoralen-UVA (PUVA) Photodamage - According to preliminary studies, taking two doses of a particular extract of Polypodium leucotomos, which includes Cantabria Farmaceutica and Fernblock, 7.5 mg/kg every day before PUVA treatment can modestly lessen edema, erythema and signs of epidermal damage. Calaguala powder also appears to lessen consequent hyperpigmentation in a few patients.
Other studies also recommend that taking a particular extract of Polypodium leucotomos containing Cantabria Farmaceutica and Difur before sun exposure may diminish photodamage in individuals whose skin is sensitized to psoralen. For topical purposes, a cream containing Polypodium leucotomos extract of different strengths i.e. 10%, 25%, or 50% may also diminish photodamage.
Psoriasis - Some initial researches recommend that taking a water extract of the rhizome of Polypodium leucotomos may improve the condition in patients with psoriasis.
Sunburn - According to some clinical researches, taking a particular extract of calaguala, which includes Cantabria Farmaceutica and Fernblock, 7.5 mg/kg every day in two doses before sun exposure can diminish epidermal damage and acute erythema.
Other studies recommend that by taking a particular extract of Polypodium leucotomos, which includes Cantabria Farmaceutica and Difur, before sun exposure may diminish photodamage. Other topical preparations of a cream possessing calaguala extract 10%, 25% and 50% may also diminish photodamage effects.
According to some clinical experiments, issue like photodamage and sunburn may get benefit by the utilization of particular Polypodium leucotomos extract, which includes Cantabria Farmaceutica and Fernblock. Such preparation are utilized in Heliocare brand name products.
Vitiligo - Preliminary proofs recommend that by taking a particular extract of calaguala, which includes ASAC Pharma and Anapsos, in a dose of 360 mg every day for five months can result in repigmentation in patients suffering from vitiligo.
However, to authenticate all these uses, more proof is required.
How Calaguala Works?
Aerial parts and rhizome are the most effective parts of Polypodium leucotomos. Few constituents of calaguala powder are ecdysone, calagualine, polypodaureia and ecdysterone.
Calaguala appears to have antioxidant impacts. Water extracts of the aerial parts of Polypodium leucotomos possess some phenolic compounds that may be responsible for its antioxidant effects. Few of these phenolic compounds are caffeic acid, number of isomers of chlorogenic acid, 3, 4-dihydroxybenzoic acid, hydroxycinnamic acid, vanillic acid, ferulic acid, 4-hydroxybenzoic acid and others acids. Polypodium leucotomos is thought to protect from sun ultra violate (UV) radiation by lessening the oxidative damage inflicted by these UV rays.
In animal models of UV exposure, pretreatment with topical application of extract of calaguala essentially decreases mast cells and vessel infiltrates when compared with placebo.
Water extract of calaguala aerial parts may also have anti-inflammatory and immunomodulating effects. Results of in vitro examinations show that calaguala powder inhibits platelet activating factor (PAF) and leukotriene B4 production. It may also diminish cytokine production and lymphocyte proliferation. Some confirmations propose that it decrease the production of interleukin-6 (IL-6), inflammatory cytokines like interleukin-2 (IL-2), tumor necrosis factor (TNF)-alpha and interferon gamma. Moreover, it appears to enhance anti-inflammatory cytokine interleukin-10 production.
According to some studies it is recommended that a particular water based extract of the rhizome of calaguala, which includes ASAC Pharma and Anapsos, also inhibits IL-2 secretion. However, it appears to essentially build up the secretion of IL-1 beta, interleukin-1 (IL-1) alph and TNF-alpha also.
In animal models, extract of Polypodium leucotomos appears to delay skin joint diseases.
What Are The Side Effects /Adverse Reactions of Calaguala?
The oral consumption of calaguala powder may cause side effects like abdominal pain or other forms of gastrointestinal upsets. However, there is lack of clinical trials that could prove these side effects of calaguala powder.
How Calaguala Interacts With Other Herbs and Supplements?
There are no known interactions of Polypodium Leucotomos with different herbs & supplements.
How Calaguala Interacts With Drugs?
There are no known interactions of calaguala powder with drugs.
How Calaguala Interacts With Foods?
There are no known interactions of Polypodium Leucotomos with different food items.
How Calaguala Interacts With Lab Tests?
There are no known interactions of Polypodium Leucotomos with different food items.
How Calaguala Interacts With Diseases and Conditions?
There are no known interactions of Polypodium Leucotomos with diseases or conditions.
What Should Be the Dose/Administration of Calaguala?
ORAL In order to prevent from sunburn, two doses of Polypodium leucotomos extract should be utilized in a dose of 7.5 mg/kg every day before taking sun bath.
Another particular extract of Polypodium leucotomos, which includes Cantabria Farmaceutica and Fernblock, has been utilized in a dosage of 240 mg thrice every day.
In lotion form, which is made of Polypodium leucotomos extract of different concentrations i.e. 10%, 25% or 50% has also been utilized.
For vitiligo, a particulate extract of calaguala, which includes Anapsos, has been utilized in a daily dosage of 360 mg for five month.
Comments
Polypodium leucotomos is a fern like plant that is commonly found in the Central American region
General Certificate of Analysis (COA)
Specification sheet links below are a standard copy of the COA less the batch or lot number and manufactures dates. Specification sheet can be dated and should only be considered as a general information. Please contact and request an up to date COA if needed for specific updated information before placing order by filling out the contact form with product name and SKU number. If ordering quantities of twenty five kilos or more contact for availability.
