Brussel Sprout Purchase & Information
Alternative Names
Brussels Sprouts
Scientific Name
Brassica Oleracea Var. Gemmifera
Why Do People Use Brussel Sprout?
Orally, brussel sprout is used for preventing cancer and boosting immune function.
Is It Safe To Use?
Likely safe when used in food amounts.
How Effective Is Brussel Sprout?
Bladder cancer. Epidemiologic research shows that eating about 1.75 cups daily of cruciferous vegetables such as brussel sprout decreases the risk of developing bladder cancer by about 30% in men and women.
Breast cancer. Epidemiological research suggests that consumption of brussel sprout is associated with a modestly reduced risk of breast cancer in premenopausal women. However, brussel sprout consumption does not seem to be associated with breast cancer risk in postmenopausal women.
Colorectal cancer. Epidemiological research suggests consumption of brussel sprout might be associated with a reduced risk of colorectal cancer
Stomach cancer. Epidemiological research suggests consumption of brussel sprout might be associated with a reduced risk of stomach cancer.
How Brussel Sprout Works?
The applicable parts of brussel sprout are the above ground parts. Brussel sprout contains glucosinolate, glucoraphanin, and its derivative, sulforaphane, which might be responsible for brussel sprout purported anticancer activity. Some research suggests the bioavailability of sulforaphane may be greater in uncooked than cooked brussel sprout. Storage of brussel sprout might reduce glucoraphanin content.
Brussel sprout glucosinolates are metabolized into indoles and isothiocyanates. Indoles might affect estrogen metabolism. Isothiocyanates seem to inhibit some phase I enzymes, induce the cytochrome P-450 system, and induce phase II enzymes (conjugating enzymes), which may provide cancer-preventive effects. Brussel sprout also contains glucobrassicin, which is broken down to indole-3-caribinole, which might also have anticancer effects.
Brussel sprout also inhibits proliferation of tumor cells.
Brussel sprout is a good source of selenium, which might also have anticancer activity.
Brussel sprout has antioxidant activity, probably due to its phenolic components such as ferulic acid. Brussel sprout also contains vitamin C. Brussel sprouts effects on phase I and phase II enzymes may also contribute to its antioxidant activity. Preliminary research suggests that sulforaphane from broccoli reduces oxidative stress in cardiovascular and kidney tissues.
Indole-3-carbinol also seems to have antiviral activity against herpes simplex virus (HSV), and human papilloma virus (HPV).
Some researchers think indole-3-carbinol might be particularly helpful against hormone-dependent cancers such as breast cancer. Indole-3-carbinol induces cytochrome P450 1A1 (CYP1A1) and 1A2 (CYP1A2), which alters estrogen metabolism. Estradiol is normally metabolized to both 16-alpha-hydroxyestrone and 2-alpha-hydroxyestrone. The 16-alpha-hydroxysestrone metabolite has both genotoxic and tumorigenic effects and is thought to increase the risk of breast and cervical cancers. Indole-3-carbinol shifts metabolism of estradiol from 16-alpha-hydroxyestrone to the weaker estrogen and more benign 2-alpha-hydroxyestrone metabolite, possibly producing a protective effect against hormone-mediated cancers.
Indole-3-carbinol also induces cytochrome P450 2B1, 2B2, 3A1, and 3A2, as well as phase II enzymes including glutathione S-transferase (GST), quinone reductase, and uridine diphosphate glucuronide transferase. The phase II enzyme induction seems to have a detoxifying effect by increasing water solubility and increasing excretion of carcinogenic toxins. There is some evidence that indole-3-carbinol might have other protective effects including antioxidant properties and might also cause cancer cell apoptosis and cell cycle arrest. The majority of evidence seems to indicate that indole-3-carbinol has a protective effect against cancer. However, there is some concern that it might enhance carcinogenicity in some cases.
Some of the effects of indole-3-carbinol on metabolism actually seem to increase carcinogenicity of certain toxins. Since indole-3-carbinol induces CYP1A1 metabolism, it can also increase conversion of procarcinogens to their active carcinogenic form. Ultimately, whether indole-3-carbinol has a cancer preventive effect or increases cancer risk in humans probably depends on several factors, including dietary factors, and duration and timing of exposure to indole-3-carbinol. For example, in animal models, there is some evidence that indole-3-carbinol has a protective role if administered before or in conjunction with a carcinogenic agent. If indole-3-carbinol is given after carcinogen exposure during the initiation phase of tumor induction, it might act as a tumor promoting agent and increase the risk of developing a tumor. However, there is some conflicting evidence.
What Are The Side Effects /Adverse Reactions of Brussel Sprout?
Orally, no side effects have been reported.
Topically, brussels sprouts can cause contact dermatitis.
How Brussel Sprout Interacts With Other Herbs and Supplements?
None known.
How Brussel Sprout Interacts With Drugs?
None known.
How Brussel Sprout Interacts With Foods?
None known.
How Brussel Sprout Interacts With Lab Tests?
None known.
How Brussel Sprout Interacts With Diseases and Conditions?
None known.
What Should Be the Dose/Administration of Brussel Sprout?
No typical dosage for burssels sprout.
Comments
None.
General Certificate of Analysis (COA)
Specification sheet links below are a standard copy of the COA less the batch or lot number and manufactures dates. Specification sheet can be dated and should only be considered as a general information. Please contact and request an up to date COA if needed for specific updated information before placing order by filling out the contact form with product name and SKU number. If ordering quantities of twenty five kilos or more contact for availability.
