Butterbur Purchase & Information
Bog Rhubarb, Blatterdock, Butter-Dock, Bogshorns, Butterfly Dock, Contre-Peste, Capdockin, Chapelière, Exwort, Feuille de Pétasite, Flapperdock, Fleur de Pétasite, Grand Bonnet, Herbe aux Teigneux, Herbe à la Peste, Japonica Petasites, Japanese Butterbur, Langwort
Pétasite, Pestwurz, Pétasite Hybride, Pétasite du Japon, Pétasite Officinal, Pétasite Japonaise, Petasites, Pétasite Vulgaire, Petasites Vulgaris, Petasites Japonicus, Petasitidis Rhizoma, Petasitidis Folium, Plague Root, Petasitidis Hybridus, Purple Butterbur, Rhizome de Pétasite, Racine de Pétasite, Umbrella Leaves
Why Do People Use Butterbur?
The oral consumption of butterbur powder is utilized for gastric ulcers, stomach upset, chronic cough, migraine headaches, anxiety problems, chills, fever, plague, whooping cough issues, insomnia, allergic rhinitis (also called hay fever) and for asthma. Other oral uses of Petasites hybridus (butterbur) are appetite stimulation and as an antispasmodic.
For topical purpose, it is generally utilized to speed up wound healing.
Is It Safe To Use?
Likely safe - It is likely safe when utilized orally and after physician’s recommendations. Extract of rhizome, which is free from the hepatotoxic pyrrolizidine alkaloid (PA), appears to have no risks when utilized for four months. So, patients should be advised to avoid butterbur products that are not labeled and are unverified as PA free.
Likely Unsafe - Butterbur powder is unsafe when hepatotoxic pyrrolizidine alkaloid contained products are used orally. Hepatotoxic pyrrolizidine alkaloid with low concentrations could cause serious veno-occlusive disease. So, patients should be advised to avoid butterbur products that are not labeled and are unverified as PA free.
Likely Unsafe for Pregnancy - In pregnancy, it is likely unsafe when utilized orally. Pyrrolizidine alkaloid contained Petasites hybridus may be hepatotoxic and may have teratogenic activity. Butterbur products (not having hepatotoxic PAs) should also be avoided during pregnancy because there is insufficient reliable information to rate the effectiveness of these products.
Likely Unsafe for Lactation - In lactation, it is likely unsafe when utilized orally. Constituents of butterbur powder such as hepatotoxic pyrrolizidine alkaloid are excreted in the milk. Butterbur products (not having hepatotoxic PAs) should also be avoided during breastfeeding because there is insufficient reliable information available to rate the safety of these products.
Likely Safe for Children - For children, butterbur is likely safe when consumed orally in appropriate doses. Some confirmations recommend that particular pyrrolizidine alkaloid free butterbur preparations are safe for children up to 6-17 years for as much as16 weeks.
How Effective Is Butterbur?
Migraine headache - Using butterbur powder orally appears to provide relief from migraine headache. A particular butterbur rhizome concentrate standardized to contain 15% isopetasin, petasin and hepatotoxic pyrrolizidine alkaloid PA free can lessen duration, intensity and frequency of migraine headache when utilized for 4 months. Such butterbur concentrate appears to lessen migraine frequency by 48%. Using standard dosage of 75 mg two times every day appears to be important for substantial benefits. Some clinical experiments demonstrate that minimum dosage of 50 mg two times every day appears not to produce appreciable benefits in adults. Experiments also suggest that extract of butterbur can diminish migraine headache frequency in 6-17 years old children.
Respiratory conditions - Some clinical experiments show that in chronic bronchitis and asthma, butterbur powder could be more beneficial than any herb. However, still more conformation are required to prove this statement.
How Butterbur Works?
Most effective parts of Petasites hybridus are the root, rhizome, and leaves. Dynamic constituents of butterbur are isopetasin , sesquiterpene compounds and petasin. Extract of butterbur also contain flavonoids, volatile oils, pyrrolizidine alkaloids and tannins. Some extracts of butterbur contain isopetasin and petasin in a dose of 7.5 mg.
Butterbur powder is considered to possess antispasmodic activity for vascular walls and smooth muscle. Anti-inflammatory effects have also been observed due to its ability to inhibit leukotriene synthesis.
In hay fever (allergic rhinitis), spetasin from butterbur lessens blood concentrations of leukotrienes and histamine. In preliminary research, butterbur appears to decrease the response of mast cells to allergens.
What Are The Side Effects /Adverse Reactions of Butterbur?
The oral consumption of butterbur powder is overall well tolerated. However, it can result in headache, belching, diarrhea, itchy eyes, drowsiness, pruritus, asthma, fatigue issues and stomach upset. But in some cases it appears to cause less fatigue and laziness than cetirizine.
The real worry about preparation of butterbur is the hepatotoxic pyrrolizidine alkaloid element. These constituents are pneumotoxic, hepatotoxic, mutagenic and carcinogenic
How Butterbur Interacts With Other Herbs and Supplements?
Hepatotoxic Pyrrolizidine Alkaloid (PA) Having Herb - The concomitant use of butterbur powder and hepatotoxic herbs is contraindicated due to the chances of exacerbated liver damage. Such herbs include boneset, alkanna, butterbur, borage, comfrey, tansy ragwort, coltsfoot, gravel root, forget-me-not, hound's tongue, hemp agrimony, golden ragwort and groundsel.
Cytochrome Inducing Herbs - Theoretically, CYP3A4 inducing herbs may increase the risk of PA toxicity caused by Petasites hybridus. CYP3A4 inducing herbs include garlic, St. John's wort, licorice, Echinacea and schisandra.
How Butterbur Interacts With Drugs?
Cytochrome Inducers - Although this interaction is only moderate but still be cautious. Theoretically, drugs that induce cytochrome may also increase the concentration of PA. Drugs that induce CYP3A4 are rifabutin, phenobarbital, carbamazepine, rifampin, phenytoin and other drugs.
How Butterbur Interacts With Foods?
How Butterbur Interacts With Lab Tests?
How Butterbur Interacts With Diseases and Conditions?
Use of butterbur powder may exacerbate following conditions:
• Liver disease
What Should Be the Dose/Administration of Butterbur?
For migraine disease prophylaxis, concentrate of butterbur rhizome, which is free of pyrrolizidine alkaloid, standardized to 15% isopetasin and petasin has been utilized in 50-100 mg dosage two times every day during meal. Doses with high quantity seem to be more beneficial and dosages with low quantity of 50 mg two times every day may not be viable in adults. Clinical experiments suggest that taking extract for 4-6 month then decreasing the dosage of butterbur increases the frequency of migraine headache again. If migraine problem is observed in children, dosage of 25 mg two times every day has been utilized in 6-9 years old children and 50 mg two times every day for kids who are 10 years old or more. Thrice every day dosing has been utilized in children who don't react to the two times every day dose.
For allergic rhinitis, a particular extract of butterbur leaves (Zeller AG, ZE 339 and Tesalin) maintained to 8 mg of petasin, has been used daily for 3-4 times as a tablet. An entire extract of butterbur root (Bioforce and Petaforce) 50 mg twice every day has also utilized for allergic rhinitis.
General Certificate of Analysis (COA)
Specification sheet links below are a standard copy of the COA less the batch or lot number and manufactures dates. Specification sheet can be dated and should only be considered as a general information. Please contact and request an up to date COA if needed for specific updated information before placing order by filling out the contact form with product name and SKU number. If ordering quantities of twenty five kilos or more contact for availability.