Gotu Kola Purchase & Information
Brahmi, Brahma-Manduki, Brahma-Buti, Centellase, Centella Asiatique, Centella Asiática and Centella, Divya, Hydrocotyle Indien, Hydrocotyle Asiatique and Hydrocotyle, Idrocotyle, Indischer Wassernabel, Indian Water Navelwort, Indian Pennywort, Ji Xue Cao, Khulakhudi, Luo De Da, Luei Gong Gen, Mandukaparni, Madecassol, Mandukig, Manduk Parani, Marsh Penny, TTFCA, Thick-Leaved Pennywort, Talepetrako, Tungchian, Tsubo-kusa, White Rot CAUTION: Please refer to separate listing for Cola Nut, Brahmi
Why Do People Use Gotu Kola?
The oral preparations of Centella asiatica (Gotu kola), like gout kola powder, are used for decreasing fatigue, depression, anxiety, Alzheimer's disease, improving intelligence and memory, wound healing, venous insufficiency including varicose veins and also for increasing longevity. Other advantages of gotu kola include swine flu, common cold and influenza, tonsillitis, sunstroke, urinary tract infection (UTI), pleurisy, jaundice, systemic lupus erythematosus (SLE), elephantiasis, gastritis, indigestion, dysentery, peptic ulcer disease, shingles, trauma, cholera, leprosy, psychiatric disorders, syphilis, asthma, epilepsy, diabetes and anemia. Gotu kola powder is also utilized for amenorrhea, contraception, hepatitis, diarrhea, abdominal pain, memory loss, tuberculosis and as an aphrodisiac.
Topically - Centella asiatica is utilized for reducing scars and for wound healing.
Parenterally - Gotu kola is utilized for bladder lesions related with schistosomiasis.
Is It Safe To Use?
Possibly Safe - Gotu kola is considered safe to use when utilized topically and for appropriate time period (up to 8 weeks). However, gotu kola has been utilized safely for period up to 12 months. But, there are some evidences that it may trigger liver toxicity in some patients.
Likely Unsafe in Pregnancy - Gotu kola powder is considered unsafe for pregnant females when utilized even for appropriate time periods. Gotu kola should be avoided in such conditions because there is inadequate information available regarding safety of gotu kola.
Avoid In Breast Feeding - Gotu kola should be avoided by breastfeeding females because there is lack of authentic information available.
How Effective Is Gotu Kola?
Gotu kola maybe consider effective in following conditions.
Oral intake of gotu kola for 4 to 8 weeks may decrease symptoms such as edema and enhance measures of circulation.
There is scarce information available to rate the effectiveness of gotu kola for following conditions:
• Deep Vein Thrombosis (DVT)
• Diabetic Microangiopathy
• Stretch Marks (Striae Gravidarum)
• Wound Healing
How Gotu Kola Works?
The most effective parts of Centella asiatica are the aerial parts. The essential constituents responsible for pharmacological impacts are saponin-containing triterpene acids, which range from 1% to 8%, and their sugar esters, including madecassic acid, asiatic acid, asiaticoside A (madecassoside) and asiaticoside B. Gotu kola also consists of vital flavonoids, oils and flavone subordinates including kaempferol, quercetin, stigmasterol, sesquiterpenes, isothankuniside and sitosterol.
In vitro studies propose that gotu kola may bind to GABA and cholecystokinin (CCK) receptors. This is the mechanism of gotu kola’s anxiolytic actions. The impacts on GABA may also be responsible for anticonvulsant, sedative and pain relieving impacts of Centella asiatica. There is some confirmation that oral intake of gotu kola may help diminish startle response in healthy people.
Many analysts think the asiatic acid, asiaticoside subsidiaries, Sm2, asiaticoside 6 may have a part in Alzheimer's disease. According to clinical experiment, gotu kola may secure neurons from toxicity of beta-amyloid.
The triterpenoid saponins appear to lessen venous pressure and increase wound healing in venous inadequacy. Asiaticoside and different terpenoids may have anti-inflammatory reactions. The terpenoid extract appears to enhance connective tissue renovation by empowering collagen synthesis, expanding fibroblast activity, improving epithelial growth and lessening capillary penetrability.
Clinical experiments also suggest that gotu kola powder may increase the production of type I collagen in scar development.
Hepatotoxicity effects also reported in some cases. The triterpenoids consist in gotu kola are thought to be because of this antagonistic impact.
What Are The Side Effects /Adverse Reactions of Gotu Kola?
Generally gotu kola powder has no side effects when utilized within usual dosages. But in a few patients, it can result in gastrointestinal upset. In some cases, Centella asiatica may also cause laziness in some individuals.
Minimum three cases of hepatotoxicity have been reported due to the utilization of gotu kola. In one case, an old lady (61 years) developed elevated liver function tests (LFTs) including ALT, AST, total bilirubin after oral intake of gotu kola (in tablets forms) for 30 days. Liver biopsy demonstrated hepatitis. The LFTs came back to normal when gotu kola was stopped. After some months patient took gotu kola again and again developed raised LFTs within 2 weeks. In second case, a 52-year-old women developed symptoms of hepatitis and increased LFTs after taking gotu kola for consecutively three weeks. Biopsy showed chronic granulomas and hepatitis and cirrhotic changes in the liver. LFTs came back to normal after stopping the use of gotu kola.
How Gotu Kola Interacts With Other Herbs and Supplements?
Gotu kola powder may interact with following supplements or herbs and show desired effects after interaction:
• Hepatotoxic Supplements & Herbs
• Sedative Herbs & Supplements
How Gotu Kola Interacts With Drugs?
Gotu kola may interact with following drugs and may increase their pharmacological or adverse side effects:
• CNS Depressants
• Hepatotoxic Drugs
How Gotu Kola Interacts With Foods?
How Gotu Kola Interacts With Lab Tests?
How Gotu Kola Interacts With Diseases and Conditions?
Gotu kola may interact with following diseases or conditions and may exacerbate the symptoms:
• Liver Disease
What Should Be the Dose/Administration of Gotu Kola?
ORAL For atherosclerosis and diabetic microangiopathy treatment, extract of gotu kola should be taken in a dosage of 60 mg thrice in whole day.
For venous insufficiency, extract of gotu kola should be taken in a dosage of 60-180 mg thrice in whole day.
To cure deep vein thrombosis (DVT) prevention during flying, extract of gotu kola should be taken in a dosage of 120 mg before three days of flight and the day after have been utilized.
TOPICAL In order to improve wound healing, 1% gotu kola cream has been utilized.
For scars treatment, gotu kola has been utilized for 6-8 weeks with the combination of Bulbine frutescens combination.
Generally, Gotu kola is utilized as herb in Tradition Ayurvedic and Chinese drugs.
The terpenoid extract of gotu kola is stated to as Centellase and TTFCA (total terpenoid fraction of Centella asiatica).
Do not mix swamp pennywort (Centella cordifolia) and cola nut (Cola acuminata). Sometime people mix Centella cordifolia as Centella asiatica (gotu kola).
General Certificate of Analysis (COA)
Specification sheet links below are a standard copy of the COA less the batch or lot number and manufactures dates. Specification sheet can be dated and should only be considered as a general information. Please contact and request an up to date COA if needed for specific updated information before placing order by filling out the contact form with product name and SKU number. If ordering quantities of twenty five kilos or more contact for availability.