Grape Purchase & Information
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Why Do People Use Grape?
Oral preparations of Vitis vinifera (Grape), like grape powder, are used for the treatment of cardiovascular disease, hemorrhoids, varicose veins, hypertension, atherosclerosis, edema associated with injury or surgery, peripheral vascular disease and for cerebral or myocardial infarction. It is also used as a mild laxative for constipation.
Grape powder may also be used for retinopathy or neuropathy, aging skin, improving wound healing, dental caries, preventing dental caries, age-related macular degeneration (ARMD), cancer prevention, liver cirrhosis, poor night vision, prevention of collagen breakdown and allergic rhinitis.
On other hand dried grapes, sultanas or raisins are utilized as an expectorant for cough.
Grape leaves is orally consumed for chronic fatigue syndrome (CFS), attention deficit-hyperactivity disorder (ADHD), heavy menstrual bleeding, diarrhea, canker sores and uterine hemorrhage.
Intravaginally - Grape leaves infusions are utilized as a douche.
Food Items - Grape leaf is used as a food particularly in Greek recipes.
Is It Safe To Use?
Likely Safe - Oral consumption of grapes is safe, especially when used in amounts commonly found in food items. Grapes and extract of grape skin have attained Generally Recognized As Safe status (GRAS) for use in food items in the United States.
Seeds extract of grape has been safely used for up to eight weeks in clinical studies. Extract of grape leaves has been safely used for up to eight weeks in a clinical study.
Avoid in Pregnancy and Lactation - Because of lack of reliable information, doctors do not advise to use grapes for breastfeeding or pregnant mothers.
How Effective Is Grape?
Grape powder may have beneficial effects for following conditions:
• Chronic venous insufficiency
• Ocular Stress
Grape may show ineffective results in following condition:
• Allergic rhinitis (Hayfever)
There is insufficient information to rate effectiveness of grape in following condition/diseases:
• Cardiovascular Disease
• Night vision
How Grape Works?
The most effective parts of Vitis vinifera are the fruit, fruit skin, leaves and seed. Grape products consist of combination of phenolic compounds including proanthocyanidins, oligomeric proanthocyanidins (OPCs), polyflavan-3-ols and flavonols.
Proanthocyanidins are the main factor producing the red color in grapes. Red grape varieties give more antioxidant as compare to blue or white grape mixtures. Red wine contains about 10 times the sum flavonoids of white wine. A relationship seems to exist between total proanthocyanidin content, phenol content and the antioxidant action of grape items.
Grape flavonoids have vasodilating, antioxidant, antiplatelet properties and anti-lipoperoxidant activity that might protect from heart disease.
Initial confirmation suggests that the delphinidin/cyanidin and proanthocyanidins delphinidin dimer may affect chromosomal damage.
Proanthocyanidins may also protect against chemotherapy drug-induced damage to ordinary cells, and minimize liver and kidney harm after overdosage of acetaminophen.
Grape seed proanthocyanidins appear to decrease the proliferation of breast cancer, gastric adenocarcinoma, prostate tumor cells and lung disease by increasing cell death and inhibiting cell growth.
Grape leaf is believed to have astringent and anti-inflammatory properties. These properties are most prominent in the red leaves.
Grape fruit are also thought to have expectorant and laxative properties.
What Are The Side Effects /Adverse Reactions of Grape?
Normally seed extract of grape has no significant side effect. However there are some reported available about abdominal pain, Headache, nausea, sore throat and cough have been reported with usage of grape seed, but these effects may happen at rates similar to placebo.
Excessive dosage of grapes, raisins, dried grapes or sultanas may lead to diarrhea because of potential laxative effects.
Grape leaves have may lead individual to diarrhea, gastrointestinal discomfort, dry mouth, dyspepsia and retching. Some other effects included headache, infections and musculoskeletal disorders.
How Grape Interacts With Other Herbs and Supplements?
Lactobacillus Acidophilus - Grape anthocyanins may inhibit the Lactobacillus acidophilus development. Concurrent administration may protect against Lactobacillus acidophilus colonization of the gastrointestinal tract; therefore physicians do not advice its use.
Vitamin C - Initial experiments suggest that patients with hypertension, who use both grape seed polyphenols 1000 mg/day and vitamin C 500 mg/day, may have decreased diastolic and systolic blood pressure. However, the possible mechanism of this combination is not known.
How Grape Interacts With Drugs?
Cytochrome P450 1A2 (CYP1A2) Substrates - Interaction rating between grape and cytochrome substrates is moderate, so be careful about this mixture. Grape juice seems to induce cytochrome P450 1A2 (CYP1A2) metabolism and may reduce the plasma levels of CYP1A2 substrates.
Phenacetin - Interaction rating between grape and phenacetin is moderate, so be careful about this combination. Grape juice can result in decrease in phenacetin concentration, but not acetaminophen plasma levels. It may reduce the levels by inducing cytochrome P450 1A2 (CYP1A2) metabolism.
Warfarin (Coumadin) - Interaction rating between grape powder and warfarin, is moderate so be careful about this mixture. Because of the tocopherol content of grape seed oil, the concomitant usage with warfarin may enhance the warfarin's impacts and the potential bleeding.
How Grape Interacts With Foods?
How Grape Interacts With Lab Tests?
How Grape Interacts With Diseases and Conditions?
What Should Be the Dose/Administration of Grape?
ORAL To treat chronic venous insufficiency, one clinical trial used a standardized extract of red wine grape AS 195 (Antistax, Boehringer Ingelheim). The dose used was 360 mg / 720 mg ingested once on daily basis. Grape seed extract, in form of capsules or tablets, is taken in a dose of 75 to 300 mg every day for three weeks followed by a maintenance dose of 40 to 80 mg every day.
In order to treat chronic venous insufficiency, seed extract of grape called proanthocyanidin, should be taken in a range of 150 to 300 mg on daily basis.
To relief from ocular stress because of glare, seed extract of grape, called proanthocyanidin, should be used in a range of 200 to 300 mg daily.
Grape seeds are normally obtained as a secondary product from manufacturing of wine.
General Certificate of Analysis (COA)
Specification sheet links below are a standard copy of the COA less the batch or lot number and manufactures dates. Specification sheet can be dated and should only be considered as a general information. Please contact and request an up to date COA if needed for specific updated information before placing order by filling out the contact form with product name and SKU number. If ordering quantities of twenty five kilos or more contact for availability.