Guggul Purchase & Information
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Why Do People Use Guggul?
The oral preparations of Commiphora mukul (Guggul), like guggul powder and guggul gum resin, are utilized for lowering high cholesterol, skin diseases, arthritis, nodulocystic acne, atherosclerosis and for weight loss.
Is It Safe To Use?
Possibly Safe - Oral and appropriate (for up to 24 weeks) usage of guggul is thought to be safe. However, there are some confirmations about the safety of guggul for long-term use up to 75 weeks as well.
Likely unsafe in Pregnancy - The oral consumption of guggul powder should be avoided in pregnancy. Its gum resin seems to stimulate uterus movements and menstrual flow.
Avoid in Lactation - Commiphora mukul should be avoided by breastfeeding females because there is inadequate information available about its safety in lactation.
How Effective Is Guggul?
Likely Effective in Nodulocystic acne
Oral consumption of guggul powder is similar to oral utilization of tetracycline in the nodulocystic acne treatment. Both ways of treatment could be effective in decreasing inflammation and relapse intensity.
Likely Ineffective in Hypercholesterolemia
Oral intake of guggul powder in a dosage of 3000 - 6000 mg in whole day may not be helpful in lowering triglycerides or total cholesterol or increasing high density lipoprotein (HDL) cholesterol in individuals on Western diets. It also appears to lower the level of low density lipoprotein (LDL) cholesterol up to 9% to 10%. It is parallel to studies of guggul in Indian populations where guggul appears to lessen the low density lipoprotein (LDL), total cholesterol and triglycerides as well.
There is limited information to rate the effectiveness of guggul powder for following conditions.
Obesity - According to some clinical researches, it is recommended that when guggul is used in combination with L-tyrosine, exercise, hydroxycitric acid, phosphate and calorie restriction may cause weight loss in a balanced way. In another study, used of a standardized extract of guggul for hypercholesterolemia in dosage of 3000-6000 mg per day for eight weeks resulted has no effect on body weight.
Osteoarthritis - Clinical experiments suggest that the use of Commiphora mukul, containing 3.5% guggulsterones, in a dose of 500 mg thrice every day may increase osteoarthritis pain. Moreover, more confirmations are required to rate safety of guggul for these uses.
How Guggul Works?
Extract of guggul is the gum resin of the Commiphora mukul tree, which is a local plant of India. The E-guggulsterone and ketonic steroids Z-guggulsterone are present in guggul concentrates.
Guggulsterones can hinder the cholesterol accumulation in the liver and appears to have an antioxidant effect on lipids. Guggulsterones appear to block the farnesoid X receptor (FXR), which diminishes the bile acids production.
It is also said that guggulsterone has thyroid-stimulating effects. It appears to enhance synthesis of T3 by speeding up the transformation of T4 into T3.
Extract form of guggul also appears to have anti-inflammatory effects. Guggul powder may decrease C-reactive protein and lipoprotein (A). Initial researches recommend that guggul may have anticoagulant and antiplatelet activity.
It is also recommended that guggulsterone has defensive effects against drug-induced myocardial necrosis.
Guggulipid may decrease the emission of sebum and restrain bacterial triglycerides metabolism, which prompts pimple formation.
What Are The Side Effects /Adverse Reactions of Guggul?
Orally - Use of Commiphora mukul can result in nausea, headaches, loose stools, vomiting, belching, diarrhea, hiccups and bloating. Guggul can also cause hypersensitivity reactions including pruritus and rash. Guggul can also be responsible for non-allergic adverse skin reactions. In one study, the occurrence of skin reactions was 3% with 1000 mg dosage of guggul used thrice daily. The seriousness of the responses ranged from pruritus to erythema and swelling of the face to bullous injury on the lower legs related with myalgias, headaches and pruritus.
There is one case of rhabdomyolysis reported in a patient who took guggul 300 mg thrice in whole day. The patient developed hemoglobinuria within two weeks of beginning of guggul with addition to enhanced aspartate aminotransferase (AST), myoglobinemia, alanine aminotransferase (ALT), creatine kinase and lactate dehydrogenase. The patient did not have any muscular symptoms. The patient’s condition improved when guggul was stopped
How Guggul Interacts With Other Herbs and Supplements?
Guggul powder may interacts with following herbs & supplements and show adverse effects:
• Herbs and Supplements Containing Anticoagulant Or Antiplatelet Properties
• Herbs with Estrogenic Activity
How Guggul Interacts With Drugs?
Commiphora mukul may show interactions of varied degree with a number of drugs, leading to exacerbation of adverse and therapeutic effects. The drugs showing interaction with guggul powder include:
• Anticoagulant/Antiplatelet Drugs
• Contraceptive Drugs
• Diltiazem (Dilacor, Cardizem, Tiazac)
• Propranolol (Inderal)
• Tamoxifen (Nolvadex)
• Thyroid Hormon
How Guggul Interacts With Foods?
There is scarce information available regarding interaction of guggul powder and various food items.
How Guggul Interacts With Lab Tests?
Commiphora mukul may derange the results of following lab tests:
• Serum Cholesterol
• Serum Triglycerides
• Thyroid Stimulating Hormone (TSH)
• Triiodothyronine (T3)
How Guggul Interacts With Diseases and Conditions?
Guggul may exacerbate the symptoms in following diseases or conditions:
• Cancers or conditions that are hormone sensitive
• Thyroid Disorders
What Should Be the Dose/Administration of Guggul?
ORAL For treatment of hypercholesterolemia, extract guggul (guggulipid) containing 75-150 mg of guggul sterones, can be used for up to 8 weeks in a dose of 1000 mg per day.
In order to cure nodulocystic acne, dosage of the guggulipid should be orally taken as equivalent up to 25 mg guggulsterones two time in whole day.
There is no difference between Guggul and Commiphora myrrha (myrrh of the bible). This plant has been utilized in preparations of Ayurvedic medicine from many decades. 600 BC ago it was quoted in the texts of Ayurvedic about the atherosclerosis treatment. In India, gugulipid is used for commercial purposes as well.
General Certificate of Analysis (COA)
Specification sheet links below are a standard copy of the COA less the batch or lot number and manufactures dates. Specification sheet can be dated and should only be considered as a general information. Please contact and request an up to date COA if needed for specific updated information before placing order by filling out the contact form with product name and SKU number. If ordering quantities of twenty five kilos or more contact for availability.