Nutritional Food Additives @ - March 13th 2013!

Licorice: Overview of Information & Purchase

Alternative Names

Acide Glycyrrhizique, Alcacuz, Acide Glycyrrhizinique
Bois Sucré, Bois Doux
Chinese Licorice, Can Cao
Deglycyrrhized Licorice
Gan Zao, Gan Cao, Glycyrrhiza, Glabra, Glycyrrhizae, Glycyrrhiza Radix, Glycyrrhizinic Acid, Glycyrrhizic Acid
Liquorice, Liquiritiae Radix, Lakritze, Liquirizia
Mulethi, Mulathi
Phyto-œstrogène, Phytoestrogen
Racine Douce, Racine de Réglisse, Régalissse, Regaliz, Radix Glycyrrhizae, Reglisse, Regaliz, Russian Licorice, Réglisse Déglycyrrhisée, Réglisse, Réglisse Russe, Réglisse Espagnole, Regliz
Subholz, Spanish Licorice, Sweet Root, Sussholz
Yashti-Madhuka, Yashti-Madhu
Zhi Gan Cao

Scientific Name:

The scientific names for licorice are Glycyrrhiza glabra var glandulifera, Glycyrrhiza glabra and Glycyrrhiza uralens. It belongs to the Leguminosae or Fabaceae family of plants.

Why do people use Licorice?

The oral preparations of Glycyrrhiza glabra (licorice), like licorice powder, are used for duodenal and gastric ulcers, bronchitis, sore throat, dyspepsia, chronic gastritis, menopausal symptoms, colic, cough, primary adrenocortical insufficiency, osteoporosis, osteoarthritis, for bacterial infections, systemic lupus erythematosus (SLE) and viral infections. Licorice powder is also used for hypokalemia, cholestatic liver disorders, chronic fatigue syndrome (CFS), malaria, hypertonia, abscesses, tuberculosis, diabetes insipidus, food poisoning and contact dermatitis.

Licorice can also be used topically as a shampoo in order to lessen sebum secretion.

Licorice components are effective in the treatment of hepatitis B and C.

In Foods & Beverages
Licorice is used as a flavoring ingredient in beverages, foods and tobacco items.

Is Licorice Safe to use?

Possibly Safe
Oral and appropriate (short term) usage of licorice is considered safe when orally taken as medicinal drugs. Licorice has attained Generally Recognized as Safe (GRAS) status in the United States. Oral and long-term use of licorice may enhance the chances of hypokalemia and hypertension.

Likely Unsafe
By using 30 grams or more of licorice every day for several continuous weeks may lead to lethal side effects such as paralysis, hypokalemia, hypertension, weakness and sometime encephalopathy in healthy individuals.

Likely Unsafe in Pregnancy
Oral consumption of licorice is considered unsafe. Licorice has estrogenic, abortifacient and steroid impacts and may lead to uterine stimulation effects as well.

Avoid In Breast Feeding
Breastfeeding females should avoid using licorice because there is inadequate information available in this regard.

How Effective is Licorice?

Licorice considered effective in following condition(s).
• Dyspepsia

The efficacy of licorice powder can’t be established in following conditions:
• Atopic dermatitis (eczema)
• Hepatitis
• Muscle cramps
• Peptic ulcers
• Weight loss

How Licorice Works?

The most effective part of Glycyrrhiza glabra is its root. Licorice has diuretic, anti-inflammatory, antispasmodic and alleviating properties.

Licorice seems to protect metabolism of prostaglandins E and F2 alpha, which recommends a possible and valuable impact on peptic ulcer. Initial studies suggest that deglycyrrhizinated licorice (DGL) may improve the peptic ulcers healing process.

Carbenoxolone is a semisynthetic derivative of glycyrrhetic acid that is utilized outside the United States for treating duodenal and gastric ulcer disease.

Glycyrrhizic acid (which is also known as glycyrrhizin or glycyrrhizinic acid) is metabolized to glycyrrhetinic acid in the digestive system. Glycyrrhetinic acid restrains renal 11-beta-hydroxysteroid dehydrogenase, diminishing change of cortisol into inactive cortisone in kidney. Cortisol is same as aldosterone for mineralocorticoid receptors in the distal portion of renal tubules, promoting water and sodium retention and potassium discharge. Over dosage of licorice ingestion can create a disorder of mineralocorticoid abundance, with increased loss of urinary potassium, hypokalemia, hypertension, alkalosis, stifled plasma renin and an increased proportion of cortisol to cortisone in the urine and plasma.

Use of licorice powder can prompt EKG changes, muscle weakness, encephalopathy, arrhythmias, paralysis and rhabdomyolysis. The increments in blood pressure and cortisol to cortisone proportion are due to glycyrrhizic acid.

Glycyrrhetinic acid has a long half life, extensive enterohepatic recirculation and a substantial volume of dissemination and it may take up to 1 to 2 weeks to improve hypokalemia.

Licorice powder can also be a reason for lessening the production of testosterone in males who consume licorice. This is because of inhibition of the enzyme 17-hydroxysteroid dehydrogenase, due to the licorice constituent glycyrrhetinic acid that converts androstenedione to testosterone.

Glycyrrhetinic acid also appears to repress 17-20 lyase, which changes 17-hydroxyprogesterone to androstenedione.

Glycyrrhizic and Glycyrrhizin acid containing intravenous preparations (Stronger Remefa S and Neominophagen C) show effects against hepatitis B and C. In vitro studies propose that glycyrrhizin decreases the generation of hepatitis B surface antigen (Hbs-Ag).

Side Effects of Licorice

Oral intake of licorice powder can lead to syndrome of excess of mineralocorticoid, increased urinary potassium loss, pseudohyperaldosteronism with water and sodium retention, alkalosis and hypokalemia. These metabolic abnormalities can cause some adverse effects like edema, hypertension, arrhythmias, EKG changes, lethargy, headache, weakness, muscle weakness, rhabdomyolysis, dropped head syndrome (DHS), paralysis, myoglobinuria, respiratory impairment, encephalopathy, acute renal failure and hyperparathyroidism as well. These effects are most likely because of when a licorice dosage of 30 grams or more is utilized on daily basis for some period. Some individuals are more sensitive to the adverse outcomes of Glycyrrhiza glabra, particularly those with kidney problems, hypertension and heart problems.

By chewing tobacco flavored with licorice powder may also lead to toxicity. Chewing licorice-flavored tobacco has been associated with suppressed renin, hypertension and aldosterone levels.

How Licorice Interacts with Herbs & Supplements?

Licorice powder may interact with following supplements & herbs and show exacerbated side effects:
• Herbs with Cardiac Glycoside Properties
• Stimulant Laxative Herbs

How Licorice Interacts with Drugs?

Glycyrrhiza glabra may interact with following drugs:
• Antihypertensive Drugs
• Corticosteroids
• Cytochromesubstrates
• Digoxin (Lanoxin)
• Diuretic Drugs
• Estrogens
• Ethacrynic Acid (Edecrin)
• Furosemide (Lasix)
• Warfarin (Coumadin)

How Licorice Interacts with Foods?

Licorice powder may interact with following food items
• Grapefruit Juice
• Salt

How Licorice Interacts with Lab Tests?

Licorice may interact with various lab tests such as:
• 17-Hydroxyprogesterone
• Blood Pressure
• Potassium
• Testosterone

How Licorice Interacts with Conditions or Diseases?

Licorice may interact with following diseases/conditions:
• Heart Disease
• Hormone Sensitive Cancers/Conditions
• Hypertension
• Hypertonia
• Hypokalemia
• Kidney Insufficiency
• Sexual Dysfunction
• Surgery

What should be the Administration or Dosage of Licorice?

For dyspepsia treatment, particular extract of multi-ingredient products including licorice (Iberogast, Medical Futures, Inc) and many other herbal products has been utilized in an amount of 1 mL thrice in whole day.


Some licorice containing products manufactured in the United States actually don't contain any licorice. Instead they consist of anise oil, which has the taste and smell known as “black licorice."

General Certificate of Analysis (COA)

Please refer to the general certificate of analysis (COA) to know more about the product. COA contains all the necessary information about a product like its date of manufacture and its batch number. If your delivery is missing in COA then please don’t hesitate to contact our customer support team. Our team will make sure that you get your COA as early as possible. To contact us, please use the email box at the end of the site’s homepage. Please don’t forget to inquire our customer support team if you intend to buy 25 kilos or more of a product. The whole sale pricing tends to differ for different products. Finally, please make sure to avoid the mix up between different products. For that, mention necessary product details like the ID, scientific and trade name of the product.

SKU 729 Licorice Product Purchase

Kilo Quantity:

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"These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease."

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