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Bitter Orange Purchase & Information

Alternative Names

Aurantii Fructus, Aurantii Fructus Immaturus, Aurantii Pericarpium, Aurantium, Bigarade, Bitter Orange Flower, Bitter Orange Peel, Chao Zhi Ke, Chisil, Citrus Aurantium Fruit, Extrait de Zeste d'Orange, Fleur d'Orange Amère, Fructus Aurantii, Fructus Aurantii Immaturus, Green Orange, Kijitsu, Methyl-Synephrine, Methyl-Synephrine HCl, Méthyl-Synéphrine HCl, Naranja Amarga, Neroli Oil, Norsynephrine, Octopamine, Octopamine HCl, Orange Amère, Orange de Séville, Orange Peel Extract, Orange Verte, Seville Orange, Shangzhou Zhiqiao, Sour Orange, Synephrine, Synéphrine, Synephrine HCl, Synéphrine HCl, Synephrine Hydrochloride, Zeste d'Orange Amère, Zhi Ke, Zhi Qiao, Zhi Shi CAUTION: Please refer to separate listings for Bergamot Oil, Oswego Tea, Raspberry Ketone, and Sweet Orange

Scientific Name

Citrus Arantium /Aurantifolia

Why Do People Use Bitter Orange?

Oral preparations of Citrus arantium (Bitter orange), like bitter orange powder, are used for dyspepsia and as appetite stimulant. Bitter orange peel and fruit are orally used for increasing lean body mass, weight loss, improving athletic performance, body building, allergic rhinitis, nasal congestion and chronic fatigue syndrome (CFS). Bitter orange flower and its oil are used orally for duodenal ulcers, gastrointestinal (GI) disturbances, regulating blood lipid levels, constipation, hyperlipidemia, lowering blood sugar in diabetes, functional disorders of gallbladder and liver, blood purification, antiflatulent, frostbite, stimulation of the heart and circulation, for kidney and bladder diseases, as a sedative for sleep disorders, anemia, general feebleness, impurities of the skin, imbalances of mineral metabolism, as a tonic, hair loss and for cancer. Topically - Bitter orange peel is used for inflammation of the conjunctiva, eyelid and retina. Other topical applications of bitter orange are for colds, retinal hemorrhage, neuralgia, headaches, rheumatic discomfort, muscular pain, phlebitis, bruises and bed sores. In Foods - Bitter orange oil is used as a flavoring ingredient in various food preparations. In Manufacturing Practices - Bitter orange oil is commercially used in cosmetics, pharmaceuticals and soaps.

Is It Safe To Use?

Likely Safe - Oral consumption of bitter orange thought to be safe if its amounts commonly found in foods items. Bitter orange powder has attained Generally Recognized as Safe (GRAS) status in the United States. Bitter orange essential oil is also considered safe to use by inhalation as aromatherapy or for topical purpose. Possibly Unsafe - Orally application of bitter orange thought to be adverse effects when consumed for medicinal purposes. Likely Safe in Children - Oral consumption of bitter orange in the amounts found in foods seems to be safe for children. Bitter orange has attained Generally Recognized as Safe (GRAS) status in the United States. Likely Safe during Pregnancy and Lactation - Oral consumption in the amounts found in foods appears to be safe during pregnancy and breastfeeding. It has attained Generally Recognized as Safe (GRAS) status in the United States.

How Effective Is Bitter Orange?

Use of bitter orange powder maybe effective in following conditions when used orally: • Tinea Corporis • Tinea Cruris • Tinea Pedis In following conditions/diseases, bitter orange is considered productive if used topically: • Tinea Corporis (Ringworm) • Cruris (Jock Itch) • Pedis (Athlete's foot) There is insufficient information to rate the safety of Citrus arantium for following condition: • Obesity

How Bitter Orange Works?

The most effective part of Citrus arantium are the flower, peel, fruit and leaves. Bitter orange has various active constituents and has several pharmacological impacts; on the other hand, the quantity of every constituent can change depending on the plant part and method of cultivation used. The flavonoid content is higher in the flower parts as compare to its leaves. The flavonoids are also present in the peel. These flavonoids include hesperidin, limonene, naringin, neohesperidin and tangaretin. It also contains synephrine and octopamine. Synephrine is basically like epinephrine. Octopamine is like norepinephrine. There are minimum six isomers of synephrine. Other isomers of synephrine can have somewhat different pharmacological impacts. It is not confirmed which isomer is present in bitter orange. Few references propose that bitter orange contains just p-synephrine. According to other studies it contains just m-synephrine, which is also called phenylephrine. Phenylephrine (m-synephrine) is the alpha-adrenergic agonist utilized as an over-the-counter nasal decongestant (Neosynephrine).

What Are The Side Effects /Adverse Reactions of Bitter Orange?

Octopamine and synephrine are adrenergic agents in bitter orange that may lead to cardiovascular and hypertension toxicity. Synephrine may cause side effects such as seizure, stroke, myocardial infarction (MI) and other serious side effects. Oral consumption of bitter orange has also been associated to a report of ischemic colitis. There is one case report that a 52-year-old woman developed ischemic colitis after ingesting supplements containing bitter orange (NaturalMax Skinny Fast, Nutraceutical Corporation) for a week. However, symptoms resolved within 2 days when she stopped using that supplement.

How Bitter Orange Interacts With Other Herbs and Supplements?

Following are some of the supplement & herbs that may interact with bitter orange powder: • Supplements & Herbs with Stimulant Properties • Panax Ginseng

How Bitter Orange Interacts With Drugs?

Following are some of the drugs that may have capacity to interact with Citrus arantium: • Caffeine • Cytochrome Substrates • Dextromethorphan (Robitussin Dm, Others) • Felodipine (Plendil) • Indinavir (Crixivan) • Midazolam (Versed) • Qt Interval-Prolonging Drugs • Stimulant Drugs

How Bitter Orange Interacts With Foods?

Following are some of the foods which may interact with bitter orange powder: • Caffeine

How Bitter Orange Interacts With Lab Tests?

Not known.

How Bitter Orange Interacts With Diseases and Conditions?

Following are some diseases or conditions that can interact with bitter orange powder: • Headache • Hypertension • Narrow-Angle Glaucoma • Long QT Interval Syndrome • Surgery • Tachyarrhythmias

What Should Be the Dose/Administration of Bitter Orange?

ORAL For weight loss or obesity, 975 mg of bitter orange extract in combination with 528 mg of caffeine and 900 mg of St. John's wort should be consumed on daily basis. Another particular multi ingredient product (Labrada, Charge), containing 150 mg of bitter orange providing 9 mg synephrine, as well as caffeine and number of other constituents should be taken two times every day. However, this product has not been shown to decrease weight. Extract of bitter orange commonly contains from 1.5% - 6% synephrine. TOPICALY In order to cure fungal skin infections, bitter orange oil is applied to the skin once daily for 1 to 3 weeks.


Bitter orange tree produces an extremely bitter and sour citrus fruit.

General Certificate of Analysis (COA)

Specification sheet links below are a standard copy of the COA less the batch or lot number and manufactures dates. Specification sheet can be dated and should only be considered as a general information. Please contact and request an up to date COA if needed for specific updated information before placing order by filling out the contact form with product name and SKU number. If ordering quantities of twenty five kilos or more contact for availability.


These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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