Bromelain Purchase & Information
Ananas, Bromelaine, Bromélaïne, Bromelains, Bromelainum, Bromelin, Bromelina, Broméline, Concentré de Protéase Végétale, Enzyme d'Ananas, Extrait d'Ananas, Pineapple Enzyme, Pineapple Extract, Fruit Bromelain, Plant Protease Concentrate, Protease CAUTION: Please refer to separate listing for Papain
Why Do People Use Bromelain?
Oral preparations of Bromelia ananas (Bromelain), like bromelain powder, are used for post-traumatic and acute postoperative swelling, for burn debridement especially of the nasal and paranasal sinuses, allergic rhinitis, for anti-inflammatory action, smooth muscle relaxation, prevention of epinephrine-induced pulmonary edema, inhibition of blood platelet aggregation, stimulation of muscle contractions, cancer prevention, enhanced antibiotic absorption, enhanced excretion of fat and shortening of labor pain. It is also used orally for mild ulcerative colitis.
Mixture of rutin and trypsin with bromelain is used orally for osteoarthritis.
Is It Safe To Use?
Possibly Safe - Oral and appropriate consumption of bromelain powder is thought to be safe in majority cases.
Avoid in Pregnancy and Breastfeeding - To rate the safety of bromelain in these conditions, there is scarce information available. So, avoid using.
How Effective Is Bromelain?
Bromelain has possibly effectiveness in following condition:
Osteoarthritis - Oral utilization of bromelain powder in combination with rutin (Phlogenzym) and trypsin appears to improve knee function and decrease the pain in patients suffering from osteoarthritis. This specific bromelain multi-ingredient product appears to be comparable to 50 mg of diclofenac (Voltaren).
Bromelia ananas is perhaps ineffective for:
Myalgia - Ingesting 300 mg of bromelain thrice every day, immediately following an intense exercise regimen, does not appear to prolong onset of muscle soreness and has no adverse effects on pain, skeletal weakness or even flexibility.
To rate the effectiveness of bromelain there is scarce and unreliable information available.
Knee Pain - There are some clinical experiments which suggest that oral consumption of bromelain can significantly decrease mild acute (duration of less than three months) knee pain in otherwise healthy patients. However, bromelain in an amount of 400 mg daily appears to be more effective compared to 200 mg daily in relieving pain, and improving physical function and stiffness of the knee.
Trauma - Clinical studies also recommend that appropriate consumption of bromelain may decrease the pain and swelling after trauma and surgery, but it doesn't appears to lessen the swelling after surgery.
Ulcerative Colitis - Anecdotal evidence recommends that consumption of bromelain may improve some symptoms of ulcerative colitis in individuals having persistent disease despite standard therapy.
How Bromelain Works?
Bromelain is a general name for proteolytic enzymes got from the fruit and stem of the pineapple. Bromelia ananas contains constituents that are responsible for inhibiting platelet aggregation and growth of malignant cells. It also has skin debridement properties and fibrinolytic activity. The platelet aggregation inhabitation activity may be associated with proteolytic action. Fibrinolytic activity and enhancement in adenosine monophosphate (AMP) may be responsible for its anti-cancer activity. Bromelain may also modify leukocyte activation and migration.
What Are The Side Effects /Adverse Reactions of Bromelain?
Bromelain may result in gastrointestinal (GI) disturbance or loose motions. Immunoglobulin E (IgE)-mediated allergic reactions to bromelain may happen and include cross-allergenicity. This may also occur with celery, wheat flour, carrot, papain, cypress pollen, fennel and grass pollen. Cross-allergenicity may also happen with individuals from the Compositae or Asteraceae plant family. Some of these herbs include chrysanthemums, echinacea, ragweed, daisies, marigolds many other herbs.
How Bromelain Interacts With Other Herbs and Supplements?
Herbs and Supplements Anticoagulant or Antiplatelet Properties - Bromelia ananas has antiplatelet and anticoagulant activities. Combination of bromelain powder with other products that have antiplatelet or anticoagulant activity may increase the risk of bleeding. Products include this category are angelica, alfalfa, arnica, aniseed, bladderwrack, asafoetida, chamomile, celery, fenugreek, clove, garlic, feverfew, horse chestnut, ginger, meadowsweet, licorice, southern and northern prickly ash, poplar, red clover, quassia and willow.
Zinc containing products may inhibit the enzymatic activity of bromelain. But there are no clinical reports of this interaction.
How Bromelain Interacts With Drugs?
Amoxicillin (Trimox, Amoxil) - Interaction rating between bromelain and amoxicillin is moderate, so be careful about this mixture. There are some reports which suggest that usage of bromelain may enhance the levels of amoxicillin.
With Antiplatelet or Anticoagulant Drugs - Interaction rating between bromelain powder and antiplatelet or anticoagulant containing drugs is moderate, so be careful about this combination. Concomittant use of this mixture may increase the potential risk of bleeding. Some of these drugs include clopidogrel (Plavix), aspirin, enoxaparin (Lovenox), dalteparin (Fragmin), indomethacin (Indocin), heparin, warfarin (Coumadin), ticlopidine (Ticlid) and others.
Tetracycline Antibiotics - Interaction rating between bromelain powder and tetracycline antibiotics is moderate, so be careful about this mixture. Clinical studies recommend that bromelain may enhance absorption and levels of tetracycline antibiotics.
How Bromelain Interacts With Foods?
Potato contains of protein inhibitor of proteolytic enzymes. Consumption of potato may inhibit bromelain activity.
Soybean consists of protein inhibitor of proteolytic enzymes. Oral consumption of soybean may inhibit bromelain activity.
How Bromelain Interacts With Lab Tests?
How Bromelain Interacts With Diseases and Conditions?
Pineapple Allergy - People allergic to pineapple may also have allergic reactions to bromelain.
Surgery - Bromelain is thought to have antiplatelet effects. Bromelain may result in excessive bleeding if used perioperatively. So, patients should stop using consuming bromelain because there is scarce and unreliable information available.
What Should Be the Dose/Administration of Bromelain?
ORAL For the treatment of osteoarthritis particular mixture of enzyme product (Phlogenzym), which consists of 100 mg of rutin, 90 mg of bromelain, 48 mg of trypsin, given as two tablets thrice every day has been used. For prolonged onset muscle soreness, 300 mg of bromelain should be consumed thrice every day right after hard exercise regimen has been used. To get relief from acute knee pain, 200 mg-400mg of bromelain should be consumed daily 30 days.
General Certificate of Analysis (COA)
Specification sheet links below are a standard copy of the COA less the batch or lot number and manufactures dates. Specification sheet can be dated and should only be considered as a general information. Please contact and request an up to date COA if needed for specific updated information before placing order by filling out the contact form with product name and SKU number. If ordering quantities of twenty five kilos or more contact for availability.