Red Clover Purchase & Information
Beebread, Clovone, Cow Clover, Daidzein, Genistein, Isoflavone, Meadow Clover, Miel des Prés, Phytoestrogen, Purple Clover, Trebol Rojo, Trèfle Commun, Trèfle des Prés, Trèfle Pourpre, Trèfle Rouge, Trèfle Rougeâtre, Trèfle Violet, Trefoil, Trifolium, Wild Clover CAUTION: Please refer to separate listings for Liverwort, Soy, Sweet Clover
Why Do People Use Red Clover?
Orally - The oral preparations of Trifolium pretense (Red clover), like red clover powder, are used for hot flashes and menopausal symptoms, tenderness (mastalgia) or cyclic breast pain, cancer prevention, premenstrual syndrome (PMS), hypercholesterolemia, indigestion, cough, whooping cough, bronchitis, asthma, and for treatment of sexually transmitted diseases (STDs).
Topically - Red clover powder can be applied on the skin for sore eyes, cancer, burns, skin sores, chronic skin diseases including psoriasis and eczema.
In foods and beverages - The solid extract of red clover is consumed commercially in various food & beverages items as a flavoring ingredient.
Is It Safe To Use?
Likely Safe - Oral consumption of red clover is generally considered safe when used in foods. Red clover has attained Generally Recognized as Safe status (GRAS) for use in various food items in the United States.
However, to rate the topical safety of red clover powder, there is insufficient and unreliable information available.
Likely Unsafe - Various adverse effects are reported with the use red clover in medicinal preparations because it has estrogenic effects in human body. However, about the topical safety of red clover in lactation and pregnancy there is scarce and unreliable information available.
Possibly Unsafe During Pregnancy and Lactation
Oral usage of red clover with combination of food items is considered unsafe in pregnant and breast feeding females.
How Effective Is Red Clover?
Red clover powder may have some beneficial results for following conditions:
There is scarce information to rate effectiveness of red clover in following conditions:
• Benign prostatic hyperplasia (BPH)
• Breast cancer
• Endometrial cancer
• Menopausal symptoms
More confirmations are required to rate the safety of red clover for other conditions or diseases.
How Red Clover Works?
The most effective part of Trifolium pratense are the flowering tops. This part of red clover consists of more than 100 various type of chemicals. Red clover consists of isoflavones, which are also known as phytoestrogens, which are structurally like estrogens. The basic isoflavones found in red clover are formononetin and biochanin A. At the point when ingested, formononetin and biochanin A are metabolized to the daidzein and isoflavones genistein respectively. Around 45% of biochanin A is changed into genistein and 60% of formononetin is changed over to daidzein. Red clover isoflavones are hydrolyzed by beta-glucosidases in the jejunum, discharging daidzein and genistein. Small amount of unhydrolyzed isoflavones remain available for use. The health impacts of these methylated isoflavones have not been assessed.
Like isoflavones from soy, red clover isoflavones may act as particular estrogen-receptor modulators (SERMs). In premenopausal females with typical endogenous estrogen levels, isoflavones may have an anti-estrogen impact. Isoflavones have a higher affinity for the beta estrogen receptor as compared to established alpha estrogen receptor. The beta-estrogen receptor prevails in the vasculature, heart, bladder and bone, which may represent some of red clover's desired impacts. It is proposed that red clover may have anti-anxiety impacts because of its beta estrogen receptor agonist action.
Osteoporosis in postmenopausal females is associated with decreasing level of estrogen. Red clover is thought to be advantageous for securing osteoporosis because of its estrogenic impacts. The isoflavone genistein also seems to specifically inhibit osteoclast action.
Dietary phytoestrogens are related with decreasing the risk of endometrial cancer. Other than their consequences for estrogen, phytoestrogenic constituent in red clover may hinder aromatase, which changes over androstenedione to estrone. Enhanced estrone is related with endometrial cancer effects. Red clover isoflavones may also have anticarcinogenic action likely because of both nonestrogenic and estrogenic mechanism. Reported antiproliferative impacts of genistein do not appear to be intervened by the estrogen receptors (ER) since these impacts have been reported both in ER-negative and ER-positive cell lines.
According to vitro analysis, formononetin metabolites and biochanin A may inhibit cytochrome P450 1B1 (CYP1B1) effects. More confirmation are required to figure out whether red clover will affect CYP1B1 drug digestion system.
What Are The Side Effects /Adverse Reactions of Red Clover?
Generally there are no side effects of red clover powder. However, some minor adverse effects are reported due to oral consumption of red clover such as rash-like reactions, headache, myalgia, vaginal spotting and nausea.
There is also an issue that red clover may lead to endometrial hyperplasia risks due to its potential estrogenic activity. But the phytoestrogens ingestion between 1 to 3 mg isoflavones every day, does not appears to enhance the potential endometrial cancer risks. Initial studies suggest that oral ingestion of red clover isoflavones in a quantity 50 mg per day does not have any major effect on endometrial growth in 45 to 53 years old female when taken for three months.
How Red Clover Interacts With Other Herbs and Supplements?
Following are some herb & supplement that can interact with red clove powder:
• Herbs and Supplements Containing Antiplatelet or Anticoagulant
• Herbs with Estrogenic Activity
How Red Clover Interacts With Drugs?
Following are some drugs which can interact with Trifolium pratense:
• Antiplatelet or Anticoagulant Drugs
• Contraceptive Drugs
• Cytochrome P450 1A2 (CYP1A2) Substrates
• Cytochrome P450 2C19 (CYP2C19) Substrates
• Cytochrome P450 2C9 (CYP2C9) Substrates
• Cytochrome P450 3A4 (CYP3A4) Substrates
• Tamoxifen (Nolvadex)
How Red Clover Interacts With Foods?
How Red Clover Interacts With Lab Tests?
How Red Clover Interacts With Diseases and Conditions?
Following are some conditions or diseases that can interact with red clove powder:
• Breast Cancer
• Coagulation Disorders
• Hormone sensitive conditions or cancers
• Protein Deficiency
What Should Be the Dose/Administration of Red Clover?
As a menopausal remedy, particular extract of red clover isoflavone (also known as Promensil) 40 to 160 mg daily should be utilized. Another particular isoflavone extract of red clover (MF11RCE, Melbrosin International) should be utilized every day in a dose of 80 mg.
For treatment of osteoporosis, particular extract of red clover (Novogen, Promensil) providing 40 mg per day of isoflavones has been utilized.
For cyclic mastalgia treatment, red clover isoflavones should be utilized 40 to 80 mg.
There is topical dosage of red clover.
Large quantities of red clover induces sterility in livestock.
General Certificate of Analysis (COA)
Specification sheet links below are a standard copy of the COA less the batch or lot number and manufactures dates. Specification sheet can be dated and should only be considered as a general information. Please contact and request an up to date COA if needed for specific updated information before placing order by filling out the contact form with product name and SKU number. If ordering quantities of twenty five kilos or more contact for availability.