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Grapefruit Purchase & Information

Alternative Names

Agrume, Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, Bioflavonoids, Bioflavonoïdes, Bioflavonoïdes d'Agrumes, Citrus, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoid Extract, Citrus Bioflavonoids, Citrus Extract, Citrus Flavones, Citrus Flavonoids, Citrus Grandis Extract, Citrus Peel Extract, Citrus Seed Extract, Cold-Pressed Grapefruit Oil, Complexe Bioflavonoïde, Complexe Bioflavonoïde de Pamplemousse, Concentré de Bioflavonoïde, CSE, Expressed Grapefruit Oil, Extrait d'Agrume, Extrait de Bioflavonoïde, Extrait de Bioflavonoïdes d'Agrumes, Extrait de Graines de Pamplemousse, Extrait de Pamplemousse, Extrait de Zeste d'Agrume, Extrait Normalisé de Pamplemousse, Flavonoïdes d'Agrumes, Grapefruit Bioflavonoid Complex, Grapefruit Seed Extract, GSE, Huile de Pamplemousse, Huile de Pamplemousse Pressée à Froid, Pamplemousse, Pamplemousse Rose, Paradisapfel, Pink Grapefruit, Pomelo, Shaddock Oil, Standardized Extract of Grapefruit, Toronja CAUTION: Please refer to separate listings for Chrysin, Diosmin, Hesperidin, Lemon, Methoxylated Flavones, Quercetin, Rue, Rutin, Sweet Orange

Scientific Name

Citrus Paradisi

Why Do People Use Grapefruit?

Oral preparations of Citrus paradise (Grapefruit), like grapefruit powder, are used for atherosclerosis, hyperlipidemia, reducing hematocrit counts, psoriasis, for cancer prevention and for obesity issues and weight loss. It is also used for the treatment of viral, bacterial and fungal infections such as Giardia lamblia, yeast infections and Entamoeba histolytica. Topically - Oil obtained from grapefruit is applied to the skin for muscle fatigue, toning the skin, hair growth and for oily skin and acne. It is also used for swine flu, common cold and flu (influenza). On other hand, seeds extract of grapefruit is used topically as a cleanser, facial cleanser, as a treatment for mild skin irritations, first-aid treatment and as a vaginal douche for vaginal candidiasis (yeast infection). It is also used as a nasal and ear rinse for treating and preventing infections, as a dental rinse for preventing gingivitis, as a gargle for sore throats, as a breath freshener and for promoting healthy gums. By Inhalation - Grapefruit vapors are used for headache, to help the body retain water, depression and as a relief from stress. Seed extract of grapefruit can be nebulized for the treatment of lung infections. In Food and Beverages - In a number of beverages and food items, grapefruit is used as a juice and this fruit and is used as a flavoring component in a number of commercial products. In manufacturing- Seed extract and grapefruit oil is used as a fragrance component in cosmetics and soaps products and as a household cleaner for vegetables, fruits, kitchen surfaces, meats and dishes. In Agriculture - Grapefruit seed extract is used as a fungicide and bactericide, an antiparasitic for animal feeds, as a mold inhibitor, as a water disinfectant and a food preservative and antioxidant.

Is It Safe To Use?

Likely Safe - Orally used grapefruit, in amounts commonly found in foods, seems safe to use. Grapefruit has Generally Recognized as Safe status (GRAS) in the US. It is also considered safe when used for medicinal purposes for appropriate time period. Seed extract of grapefruit has been safely used in several clinical studies. Possibly Unsafe - Initial experiments suggest that consuming one forth or more daily of grapefruit juice may lead to increased risk of breast cancer by 25% - 30% in postmenopausal women. Grapefruit juice may decrease the estrogen metabolism resulting in increased level of endogenous estrogen. More confirmation are required to validate this finding. Avoid In Pregnancy and Lactation - To rate the effectiveness of grapefruit, particularly in medicinal preparations, during these conditions, there is scarce and insufficient information available. Therefore, doctors do not advice the use of these products in pregnancy and breastfeeding.

How Effective Is Grapefruit?

Grapefruit powder maybe effective for following condition(s), but the data available in this regard is insufficient: • Asthma

How Grapefruit Works?

The most effective parts of Citrus paradise are the fruit, oil from the peel, juice and seed concentrate. Grapefruit consists of high amount of fiber, large amount of pectin, vitamin C, potassium and other nutrients. Other constituents include flavonoids, for example, furanocoumarins and naringin including bergamottin. Grapefruit seeds consist of various constituents including nomilin, naringin, nomilinic-acid-17-O-beta-D-glucoside, deacetyl-nomilin, limonol, deacetyl-nomilinic-acid-17-O-beta-D-glucoside, 7-obacunol, deoxy-limonol, epi-iso-obacunoic-acid-17-O-beta-D-glucoside, obacunone, trans-obacunoic-acid-17-O-beta-D-glucoside and iso-obacunoic-acid-17-O-beta-D-glucoside. Because of their flavonoid content, grapefruit and different citrus fruits products are being investigated for cardiovascular disease. Healthy individuals who drink grapefruit juice appear to have a transient prolongation of the QT period on electrocardiogram (ECG). Grapefruit flavonoids are thought to close cardiovascular potassium channels and consequently diminish heart repolarization. This proposes a possible antiarrhythmic impact of grapefruit juice. The potential advantages of grapefruit in asthma may be because of antioxidant properties of vitamin C or other grapefruit constituents. Commercially available extract of citrus seed utilized at a concentration of 0.5% has been accounted to inhibit the in vitro development of some yeasts, bacteria and molds (Staph. aureus, Streptococcus species, Enterobacter, enterococci, Candida, E. coli, Aspergillus, Geotrichum and Penicillium species). Seed extract obtained from grapefruit has been known to decrease numbers of Salmonella typhimurium when scattered on chicken skins but this has no impact in controlling fungal growth on unshelled peanuts. Research also demonstrates that using grapefruit juice hinders organic anion transport polypeptides (OATPs), which results in decreased bioavailability of some oral medications, for example, fexofenadine (Allegra) and numerous others.

What Are The Side Effects /Adverse Reactions of Grapefruit?

There is no significant side effect reported due to the oral consumption of grapefruit. There is some issues about grapefruit consumption and breast cancer risk. According to initial experiments, postmenopausal females who utilize one forth or more of a whole grapefruit every day have a 25% to 30% increase in the potential risks of developing breast cancer. Grapefruit is believed to be a strong inhibitor of cytochrome (P450 3A4), which metabolizes estrogen. Utilizing excessive amount of grapefruit may tremendously enhance the level of endogenous estrogen and therefore enhance the potential risks of breast cancer. There is no side effect reported when grapefruit is consumed in balanced amount.

How Grapefruit Interacts With Other Herbs and Supplements?

Following is the supplement which may interact with grapefruit powder: • Red Yeast

How Grapefruit Interacts With Drugs?

Citrus paradise may interact with following drugs: • Acebutolol (Sectral) • Aliskiren (Rasilez, Tekturna) • Amiodarone (Cordarone) • Amprenavir (Agenerase) • Artemether (Paluther, Artenam) • Atorvastatin (Lipitor) • Benzodiazepines • Buspirone (Buspar) • Caffeine • Calcium Channel Blockers • Carbamazepine (Tegretol) • Carvedilol (Coreg) • Cisapride (Propulsid) • Clomipramine (Anafranil) • Cyclosporine (Sandimmune, Neoral) • Cytochrome Substrates • Dextromethorphan (Robitussin Dm And Others) • Erythromycin • Estrogens • Etoposide (Vepesid) • Fexofenadine (Allegra) • Fluvoxamine (Luvox) • Itraconazole (Sporanox) • Levothyroxine (Synthroid And Others) • Losartan (Cozaar) • Lovastatin (Mevacor) • Methadone (Dolophine) • Methylprednisolone • Nilotinib (Tasigna) • Organic Anion-Transporting Polypeptide Substrates • Praziquantel (Biltricide) • Saquinavir (Fortovase, Invirase) • Scopolamine • Sildenafil (Viagra) • Simvastatin (Zocor) • Terfenadine (Seldane) • Warfarin (Coumadin)

How Grapefruit Interacts With Foods?

Grape fruit powder may interact with following foods: • Tonic Water • Wine

How Grapefruit Interacts With Lab Tests?

Citrus paradise may alter the results of following lab tests: • Drug Assays • Hematocrit

How Grapefruit Interacts With Diseases and Conditions?

Use of grapefruit powder may increase the risk of: • Breast Cancer

What Should Be the Dose/Administration of Grapefruit?

There is no oral or topical dosage of grapefruit.


Interaction of grapefruit juice and fruit are well documented. The composition of the grapefruit may be change by the species, the process used to extract the juice and the growing conditions. Because grapefruit juice is not standardized, use as an adjunct to drug therapy is not recommended. Grapefruit seed extract is processed from grapefruit seeds and pulp obtained as a byproduct from grapefruit juice production. Vegetable glycerin is added to the final product to reduce acidity and bitterness.

General Certificate of Analysis (COA)

Specification sheet links below are a standard copy of the COA less the batch or lot number and manufactures dates. Specification sheet can be dated and should only be considered as a general information. Please contact and request an up to date COA if needed for specific updated information before placing order by filling out the contact form with product name and SKU number. If ordering quantities of twenty five kilos or more contact for availability.


These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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